Name: CD284/TLA4 [PTR1381] recombinant mouse mAb
SKU: WM1266
Price: 268 USD
Availability: InStock

Product details

Background:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Specifications

Target	CD36
Reactivity	Human
Applications	FC, ELISA
MW(Calculated)
MW(Observed)	95kD
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Formulation	Phosphate-buffered solution
Source
Purification	Recombinant Expression and Affinity purified
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	Please check the information on the tube
Clonality	Monoclonal
Clone Number	PTR1384
Immunogen	Purified recombinant human CD284
Sequence
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD284 protein.
Gene Name	TLR4
Protein Name	Toll-like receptor 4
Other Name	TLR4; / Toll-like receptor 4; / hToll; / CD antigen CD284
Species	Human
Gene ID-1	948
Uniprot	O00206,
Species.1	Mouse
Gene ID-2
Uniprot.1	Q9QUK6,
Species.2	Rat
Gene ID-3
Uniprot.2	Q07969
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Early endosome . Cell projection, ruffle . Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. .
Tissue Expression	Adipocyte,Liver,Mammary gland,Milk,Placenta,Platelet,Skeletal muscle,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction
Research Areas	>>PPAR signaling pathway; / >>Phagosome; / >>AMPK signaling pathway; / >>ECM-receptor interaction; / >>Hematopoietic cell lineage; / >>Adipocytokine signaling pathway; / >>Insulin resistance; / >>Fat digestion and absorption; / >>Cholesterol metabolism; / >>Malaria; / >>Diabetic cardiomyopathy; / >>Lipid and atherosclerosis
Function	Disease:Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:611488]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.,Domain:The TIR domain mediates interaction with NOX4.,Function:Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,polymorphism:Allele TLR4*B (Gly-299, Ile-399) is associated with a blunted response to inhaled LPS.,PTM:N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 21 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4.,tissue specificity:Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.,
RRID

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CD284/TLA4 [PTR1381] recombinant mouse mAb

Product details

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CD284/TLA4 [PTR1381] recombinant mouse mAb

Product details

Specifications

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