Price range: $268.00 through $328.00
Background:
CD38 is a type II transmembrane glycoprotein with a molecular weight of 42 kDa. It is mainly expressed in plasma cells, pre-B cells, activated B cells, thymocytes and activated T cells. 90% of CD34 positive cells also express CD38. It is used to study the role of activated T cells in autoimmune diseases and immune deficiency diseases, and to diagnose multiple myeloma (plasmacytoma). It is a useful marker in the immunotyping of acute leukemia.
| Target | CD38 |
| Reactivity | Human |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 34kD |
| MW(Observed) | 40kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | ABT-CD38 |
| Immunogen | Synthesized peptide derived from human CD38 AA range: 200-300 |
| Sequence | |
| Specificity | The antibody can specifically recognize human CD38 protein. |
| Gene Name | CD38 |
| Protein Name | ADP-ribosyl cyclase 1 (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38) |
| Other Name | Acute lymphoblastic leukemia cells antigen CD38; / ADP ribosyl cyclase 1; / ADP ribosyl cyclase; / ADP ribosyl cyclase/cyclic ADP-ribose hydrolase; / ADP-ribosyl cyclase 1; / ADPRC 1; / ADPRC1; / cADPr hydrolase 1; / CD 38; / CD38; / CD38 antigen; / p45; / CD38 antigen; / CD38 molecule; / Cd38-rs1; / CD38_HUMAN; / CD38H; / Cyclic ADP ribose hydrolase; / Cyclic ADP ribose hydrolase 1; / Cyclic ADP-ribose hydrolase 1; / Ecto nicotinamide adenine dinucleotide glycohydrolase; / I-19; / I19; / Mouse; / Lymphocyte differentiation antigen CD38; / NAD; / +; / nucleosidase; / NIM-R5 antigen; / NIMR5 antigen; / Mouse; / OTTHUMP00000158633; / OTTHUMP00000217743; / p45; / T10 |
| Species | Human |
| Gene ID-1 | 952 |
| Uniprot | P28907 |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | CD38 is a type II transmembrane glycoprotein with a molecular weight of 42 kDa. It is mainly expressed in plasma cells, pre-B cells, activated B cells, thymocytes and activated T cells. 90% of CD34 positive cells also express CD38. It is used to study the role of activated T cells in autoimmune diseases and immune deficiency diseases, and to diagnose multiple myeloma (plasmacytoma). It is a useful marker in the immunotyping of acute leukemia. |
| Cellular Localization | Membranous |
| Tissue Expression | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Nicotinate and nicotinamide metabolism; / >>Metabolic pathways; / >>Calcium signaling pathway; / >>Hematopoietic cell lineage; / >>Oxytocin signaling pathway; / >>Salivary secretion; / >>Pancreatic secretion |
| Function | Catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,Function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma., |
| RRID |
