Cdc42EP2 Polyclonal Antibody
Ucallm_WP11539-50
Price range: $268.00 through $328.00
Product details
Background:
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011],
Specifications
| Size | 50μL/100μL |
| Target | Cdc42EP2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BORG1. AA range:10-59 |
| Specificity | Cdc42EP2 Polyclonal Antibody detects endogenous levels of Cdc42EP2 protein. |
| Gene Name | CDC42EP2 |
| Protein Name | Cdc42 effector protein 2 |
| Other Name | CDC42EP2; / BORG1; / CEP2; / Cdc42 effector protein 2; / Binder of Rho GTPases 1 |
| Species | Human |
| Gene ID | 10435 |
| Uniprot | O14613, |
| Species.1 | Mouse |
| Gene ID.1 | 104252 |
| Uniprot.1 | Q8JZX9, |
| Species.2 | Rat |
| Gene ID.2 | 309175 |
| Uniprot.2 | Q5PQP4 |
| Cellular Localization | Endomembrane system; Peripheral membrane protein . Cytoplasm, cytoskeleton . |
| Tissue Expression | Highly expressed in the heart. Weakly expressed in the pancreas and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The CRIB domain mediates interaction with CDC42.,Function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart. Weakly expressed in the pancreas and liver., |
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