Price range: $268.00 through $328.00
Background:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],
| Size | 50μL/100μL |
| Target | CDX2 |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; IF 1:50-200; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM-CDX2 |
| Immunogen | Synthesized peptide derived from human CDX-2 AA range: 150-265 |
| Specificity | This antibody detects endogenous levels of CDX-2 protein. |
| Gene Name | CDX2 CDX3 |
| Protein Name | Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2) |
| Other Name | |
| Species | Human |
| Gene ID | 1045 |
| Uniprot | P47902;Q99626;O14627 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | Detected in small intestine, colon and pancreas. |
| Signaling_pathway | Human Diseases >> Cancer: specific types >> Gastric cancer |
| Research Areas | >>Gastric cancer |
| Function | Function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain., |
