CDYL1 Polyclonal Antibody
Ucallm_WP2140-50
Price range: $268.00 through $328.00
Product details
Background:
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CDYL1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 60-140 |
| Specificity | CDYL1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | CDYL CDYL1 |
| Protein Name | Chromodomain Y-like protein (CDY-like) (EC 2.3.1.48) |
| Other Name | |
| Species | Human |
| Gene ID | 9425 |
| Uniprot | Q9Y232 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 2]: Nucleus . Chromosome . Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). . |
| Tissue Expression | Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554). Ubiquitous (PubMed:19808672). Expressed at moderate levels in all tissues examined (PubMed:19808672). Isoform 2: Most abundantly expressed isoform (PubMed:19808672). |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,Function:Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a preference for histone H4.,miscellaneous:Interaction with HDAC1 or HDAC2 prevents coenzyme A binding.,similarity:Contains 1 chromo domain.,subunit:Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain.,tissue specificity:Ubiquitous. Expressed at moderate levels in all tissues examined., |
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