Price range: $268.00 through $328.00
Background:
Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009],
| Size | 50μL/100μL |
| Target | Cerebellin 3 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 27kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CBLN3. AA range:131-180 |
| Specificity | Cerebellin 3 Polyclonal Antibody detects endogenous levels of Cerebellin 3 protein. |
| Gene Name | CBLN3 |
| Protein Name | Cerebellin-3 |
| Other Name | CBLN3; / Cerebellin-3 |
| Species | Human |
| Gene ID | 643866 |
| Uniprot | Q6UW01, |
| Species.1 | Mouse |
| Gene ID.1 | 56410 |
| Uniprot.1 | Q9JHG0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum . Golgi apparatus, cis-Golgi network . Secreted . Cell junction, synapse . In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May be involved in synaptic functions in the CNS.,similarity:Contains 1 C1q domain.,subcellular location:Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2.,subunit:Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4., |
