CHD3 [C-term] mouse mAb
Ucallm_WM0586-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CHD3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ICC, IP |
| MW(Calculated) | |
| MW(Observed) | 260kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:400 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 12B3 |
| Immunogen | Purified recombinant human CHD3 (C-terminus) protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CHD3 (C-terminus) and does not cross-react with related proteins. |
| Gene Name | chd3 |
| Protein Name | |
| Other Name | 226; / 2600010P09Rik; / AF020312; / ATP dependent helicase CHD3; / ATP-dependent helicase Chd3; / CHD-3; / Chd3; / CHD3_HUMAN; / Chd7; / Chromodomain-helicase-DNA-binding protein 3; / hZFH; / MGC40857; / Mi 2 autoantigen 240 kDa protein; / Mi 2a; / Mi-2 autoantigen 240 kDa protein; / Mi2 ALPHA; / Mi2-alpha; / Prp7; / Prp9 1; / ZFH; / Zinc finger helicase; / zinc-finger helicase; / Snf2-like; / . |
| Species | Human |
| Gene ID | 1107 |
| Uniprot | Q12873 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, PML body . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase and mitosis. . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Genetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling |
| Research Areas | |
| Function | Disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,sequence Caution:Differs from position 1967 onward for unknown reasons.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts via its C-terminal region with HABP4.,tissue specificity:Widely expressed., |
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