CHD4 mouse mAb
Ucallm_WM0669-50
Price range: $268.00 through $328.00
Product details
Background:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
Specifications
| Size | 50μL/100μL |
| Target | CHD4 |
| Reactivity | Human |
| Applications | WB, CoIP |
| MW(Calculated) | |
| MW(Observed) | 260kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; IP 1:50-200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 8B8 |
| Immunogen | Purified recombinant human CHD4 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins. |
| Gene Name | CHD4 |
| Protein Name | |
| Other Name | CHD4; / Chromodomain-helicase-DNA-binding protein 4; / CHD-4; / ATP-dependent helicase CHD4; / Mi-2 autoantigen 218 kDa protein; / Mi2-beta |
| Species | Human |
| Gene ID | 1108 |
| Uniprot | Q14839 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. . |
| Tissue Expression | Epithelium,Pancreas,Skin,Uterus, |
| Signaling_pathway | Genetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling |
| Research Areas | >>Human papillomavirus infection; / >>Viral carcinogenesis |
| Function | Disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression., |
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