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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/CK7 Monoclonal Antibody [12D7]
SKU: WM0998 Categories: ,

CK7 Monoclonal Antibody [12D7]

Ucallm_WM0998-50

Price range: $268.00 through $328.00

SKU: WM0998-50
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Product details

Background:
keratin 7(KRT7) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],

Specifications

TargetCytokeratin 7
ReactivityHuman, Mouse, Rat
ApplicationsIF, WB, IHC, IP
MW(Calculated)
MW(Observed)54kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioIF 1:50-200; WB 1:1000-2000; IHC 1:200; IP 1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationPBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number12D7
ImmunogenSynthetic Peptide of CK7
Sequence
SpecificityThe antibody detects endogenous CK7 proteins.
Gene NameKRT7 SCL
Protein NameKeratin type II cytoskeletal 7
Other NameKRT7; / SCL; / Keratin, type II cytoskeletal 7; / Cytokeratin-7; / CK-7; / Keratin-7; / K7; / Sarcolectin; / Type-II keratin Kb7
SpeciesHuman
Gene ID-13855
UniprotP08729,
Species.1Mouse
Gene ID-2110310
Uniprot.1Q9DCV7,
Species.2Rat
Gene ID-3300242
Uniprot.2Q6IG12
Organism-4
Gene ID-4
SwissProt-4
Backgroundkeratin 7(KRT7) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
Cellular LocalizationCytoplasm .
Tissue ExpressionExpressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
Signaling_pathway
Research Areas
FunctionFunction:Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).,induction:Up-regulated by retinoic acid.,mass spectrometry: PubMed:11840567,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Arg-20 is dimethylated, probably to asymmetric dimethylarginine.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.,tissue specificity:Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.,
RRID
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