Name: U-Blot® COX1 Rabbit mAb
SKU: WR4983
Price: 268 USD
Availability: InStock

U-Blot® COX1 Rabbit mAb

Ucallm_WR4983-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR4983-50

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Product details

Background:This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Specifications

Size	50μL/100μL
Target	COX1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	69kD
MW(Observed)	70kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1215R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	PTGS1
Protein Name	Prostaglandin G/H synthase 1
Other Name	PTGS1; / COX1; / Prostaglandin G/H synthase 1; / Cyclooxygenase-1; / COX-1; / Prostaglandin H2 synthase 1; / PGH synthase 1; / PGHS-1; / PHS 1; / Prostaglandin-endoperoxide synthase 1
Species	Human
Gene ID	5742
Uniprot	P23219,
Species.1	Mouse
Gene ID.1	19224
Uniprot.1	P22437,
Species.2	Rat
Gene ID.2	24693
Uniprot.2	Q63921
Cellular Localization	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Tissue Expression	Brain,Lung fibroblast,Platelet,
Signaling_pathway	Organismal Systems >> Immune system >> Platelet activation
Research Areas	>>Arachidonic acid metabolism; / >>Metabolic pathways; / >>Platelet activation; / >>Serotonergic synapse; / >>Regulation of lipolysis in adipocytes
Function	Catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,Function:May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,