COX17 Polyclonal Antibody
Ucallm_WP11766-50
Price range: $268.00 through $328.00
Product details
Background:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provi
Specifications
| Size | 50μL/100μL |
| Target | COX17 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 7kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human COX17. AA range:1-50 |
| Specificity | COX17 Polyclonal Antibody detects endogenous levels of COX17 protein. |
| Gene Name | COX17 |
| Protein Name | Cytochrome c oxidase copper chaperone |
| Other Name | COX17; / Cytochrome c oxidase copper chaperone |
| Species | Human |
| Gene ID | 10063 |
| Uniprot | Q14061, |
| Species.1 | Mouse |
| Gene ID.1 | 12856 |
| Uniprot.1 | P56394 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion intermembrane space . Cytoplasm . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Thermogenesis |
| Function | Function:Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.,similarity:Belongs to the COX17 family.,tissue specificity:Ubiquitous., |
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