Price range: $268.00 through $328.00
Background:The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],
| Size | 50μL/100μL |
| Target | Cyclophilin B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 24kD |
| MW(Observed) | 20kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0969R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | PPIB |
| Protein Name | Peptidyl-prolyl cis-trans isomerase B |
| Other Name | PPIB; / CYPB; / Peptidyl-prolyl cis-trans isomerase B; / PPIase B; / CYP-S1; / Cyclophilin B; / Rotamase B; / S-cyclophilin; / SCYLP |
| Species | Human |
| Gene ID | 5479 |
| Uniprot | P23284, |
| Species.1 | Mouse |
| Gene ID.1 | 19035 |
| Uniprot.1 | P24369, |
| Species.2 | Rat |
| Gene ID.2 | 64367 |
| Uniprot.2 | P24368 |
| Cellular Localization | Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). . |
| Tissue Expression | Brain,Fetal brain cortex,Prostate,Skin, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,Caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., |
