Price range: $268.00 through $328.00
Background:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
| Target | Dkk-3 |
| Reactivity | Human, Monkey |
| Applications | WB, FC, ELISA |
| MW(Calculated) | 38kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | Affinity purification |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 14A10 |
| Immunogen | Purified recombinant fragment of human Dkk-3 expressed in E. Coli. |
| Sequence | |
| Specificity | Dkk-3 Monoclonal Antibody detects endogenous levels of Dkk-3 protein. |
| Gene Name | DKK3 |
| Protein Name | Dickkopf-related protein 3 |
| Other Name | DKK3; / REIC; / Dickkopf-related protein 3; / Dickkopf-3; / Dkk-3; / hDkk-3 |
| Species | Human |
| Gene ID-1 | 27122 |
| Uniprot | Q9UBP4 |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Secreted. |
| Tissue Expression | Highest expression in heart, brain, and spinal cord. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Inhibitor of Wnt signaling pathway .,PTM:N-glycosylated.,similarity:Belongs to the dickkopf family.,tissue specificity:Highest expression in heart, brain, and spinal cord., |
| RRID |
