DNA pol ε 4 Polyclonal Antibody
Ucallm_WP12035-50
Price range: $268.00 through $328.00
Product details
Background:
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004],
Specifications
| Size | 50μL/100μL |
| Target | DNA pol ε 4 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 12kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POLE4. AA range:61-110 |
| Specificity | DNA pol ε 4 Polyclonal Antibody detects endogenous levels of DNA pol ε 4 protein. |
| Gene Name | POLE4 |
| Protein Name | DNA polymerase epsilon subunit 4 |
| Other Name | POLE4; / DNA polymerase epsilon subunit 4; / DNA polymerase II subunit 4; / DNA polymerase epsilon subunit p12 |
| Species | Human |
| Gene ID | 56655 |
| Uniprot | Q9NR33, |
| Species.1 | Mouse |
| Gene ID.1 | 66979 |
| Uniprot.1 | Q9CQ36 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Cervix carcinoma,Skin, |
| Signaling_pathway | |
| Research Areas | >>DNA replication; / >>Base excision repair; / >>Nucleotide excision repair |
| Function | Catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,Function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex., |
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