Product details
Background:
DPP9 rabbit pAb
Ucallm_WP9015-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DPP9 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 95kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DPP9 |
| Specificity | This antibody detects endogenous levels of DPP9 at Human, Mouse |
| Gene Name | DPP9 DPRP2 |
| Protein Name | Dipeptidyl peptidase 9 (DP9) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) |
| Other Name | |
| Species | Human |
| Gene ID | 91039 |
| Uniprot | Q86TI2, |
| Species.1 | Mouse |
| Gene ID.1 | 224897 |
| Uniprot.1 | Q8BVG4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cytoplasm, cytosol .; [Isoform 2]: Nucleus . |
| Tissue Expression | Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain. |
| Signaling_pathway | |
| Research Areas | |
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 . Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 . Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation . The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition . |
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