Name: DRD2 Polyclonal Antibody
SKU: WP2904
Price: 268 USD
Availability: InStock

DRD2 Polyclonal Antibody

Ucallm_WP2904-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP2904-100

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Product details

Background:

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	DRD2
Reactivity	Human, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	48kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 170-250
Specificity	DRD2 Polyclonal Antibody detects endogenous levels of protein.
Gene Name	DRD2
Protein Name	D(2) dopamine receptor (Dopamine D2 receptor)
Other Name
Species	Human
Gene ID	1813
Uniprot	P14416,
Species.1	Mouse
Gene ID.1
Uniprot.1	P61168,
Species.2	Rat
Gene ID.2
Uniprot.2	P61169
Cellular Localization	Cell membrane; Multi-pass membrane protein . Golgi apparatus membrane; Multi-pass membrane protein .
Tissue Expression	[Isoform 1]: Expressed in the anterior pituitary gland.; [Isoform 2]: Expressed in the anterior pituitary gland.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas	>>Rap1 signaling pathway; / >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Gap junction; / >>Dopaminergic synapse; / >>Parkinson disease; / >>Cocaine addiction; / >>Alcoholism
Function	Disease:Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.,Disease:It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia.,Function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2.,