Product details
Background:
DYH12 rabbit pAb
Ucallm_WP3857-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | DYH12 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | 340kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human DYH12 AA range: 565-615 |
| Specificity | This antibody detects endogenous levels of DYH12 at Human/Mouse/Rat |
| Gene Name | DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19 |
| Protein Name | DYH12 |
| Other Name | |
| Species | Human |
| Gene ID | 201625 |
| Uniprot | Q6ZR08, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3V0Q1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q923J6 |
| Cellular Localization | Cytoplasm, cytoskeleton, cilium axoneme . |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Pathways of neurodegeneration - multiple diseases |
| Function | Caution:Although related to the dynein heavy chain family, it is much shorter than the other members of the family and lacks essential conserved regions. Its function as dynein heavy chain is therefore unsure.,Caution:Was originally derived from a readthrough transcript including ASB14 and DNAH12. DNHD2 was thought to be a distinct gene.,Domain:Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.,Function:Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.,similarity:Belongs to the dynein heavy chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains., |
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