Price range: $268.00 through $328.00
Background:
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | EDG-3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EDG3. AA range:115-164 |
| Specificity | EDG-3 Polyclonal Antibody detects endogenous levels of EDG-3 protein. |
| Gene Name | S1PR3 |
| Protein Name | Sphingosine 1-phosphate receptor 3 |
| Other Name | S1PR3; / EDG3; / Sphingosine 1-phosphate receptor 3; / S1P receptor 3; / S1P3; / Endothelial differentiation G-protein coupled receptor 3; / Sphingosine 1-phosphate receptor Edg-3; / S1P receptor Edg-3 |
| Species | Human |
| Gene ID | 1903 |
| Uniprot | Q99500, |
| Species.1 | Mouse |
| Gene ID.1 | 13610 |
| Uniprot.1 | Q9Z0U9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway |
| Research Areas | >>Sphingolipid signaling pathway; / >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver., |
