Product details
Background:
ELK4 rabbit pAb
Ucallm_WP7448-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ELK4 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 47kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ELK4 |
| Specificity | This antibody detects endogenous levels of ELK4 at Human, Mouse |
| Gene Name | ELK4 SAP1 |
| Protein Name | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 2005 |
| Uniprot | P28324, |
| Species.1 | Mouse |
| Gene ID.1 | 13714 |
| Uniprot.1 | P41158 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway |
| Research Areas | |
| Function | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. |
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