Epiregulin Polyclonal Antibody
Ucallm_WP15965-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015],
Specifications
| Size | 50μL/100μL |
| Target | Epiregulin |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 71-120 |
| Specificity | The antibody detects endogenous Epiregulin |
| Gene Name | EREG |
| Protein Name | Proepiregulin [Cleaved into: Epiregulin (EPR)] |
| Other Name | Proepiregulin [Cleaved into: Epiregulin; / EPR; / ] |
| Species | Human |
| Gene ID | 2069 |
| Uniprot | O14944, |
| Species.1 | Mouse |
| Gene ID.1 | 13874 |
| Uniprot.1 | Q61521 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Epiregulin]: Secreted, extracellular space .; [Proepiregulin]: Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. |
| Signaling_pathway | Human Diseases >> Cancer: specific types >> Colorectal cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>ErbB signaling pathway; / >>PI3K-Akt signaling pathway; / >>Colorectal cancer |
| Function | Function:May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.,similarity:Contains 1 EGF-like domain.,tissue specificity:In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon., |
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