Name: ERK 3 Monoclonal Antibody
SKU: WM0177
Price: 268 USD
Availability: InStock

ERK 3 Monoclonal Antibody

Ucallm_WM0177-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM0177-50

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Product details

Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	ERK 3
Reactivity	Human
Applications	WB, FC, ELISA
MW(Calculated)	83kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	5C4
Immunogen	Purified recombinant fragment of human ERK 3 expressed in E. Coli.
Specificity	ERK 3 Monoclonal Antibody detects endogenous levels of ERK 3 protein.
Gene Name	MAPK6
Protein Name	Mitogen-activated protein kinase 6
Other Name	MAPK6; / ERK3; / PRKM6; / Mitogen-activated protein kinase 6; / MAP kinase 6; / MAPK 6; / Extracellular signal-regulated kinase 3; / ERK-3; / MAP kinase isoform p97; / p97-MAPK
Species	Human
Gene ID	5597
Uniprot	Q16659
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
Tissue Expression	Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
Signaling_pathway	Organismal Systems >> Immune system >> IL-17 signaling pathway
Research Areas	>>IL-17 signaling pathway
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation.,Function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,PTM:Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.,

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ERK 3 Monoclonal Antibody

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ERK 3 Monoclonal Antibody

Product details

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