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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/FABP5 Polyclonal Antibody
SKU: WP2782 Categories: ,

FABP5 Polyclonal Antibody

Ucallm_WP2782-50

Price range: $268.00 through $328.00

SKU: WP2782-100
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Product details

Background:

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011],

Specifications

Size50μL/100μL
TargetFABP5
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)14kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 40-120
SpecificityFABP5 Polyclonal Antibody detects endogenous levels of protein.
Gene NameFABP5
Protein NameFatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)
Other Name
SpeciesHuman
Gene ID2171
UniprotQ01469,
Species.1Mouse
Gene ID.1
Uniprot.1Q05816,
Species.2Rat
Gene ID.2
Uniprot.2P55053
Cellular LocalizationCytoplasm . Nucleus . Cell junction, synapse . Cell junction, synapse, postsynaptic density . Secreted . Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity). .
Tissue ExpressionKeratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585).
Signaling_pathwayOrganismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas>>PPAR signaling pathway
FunctionDomain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,Function:High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,tissue specificity:Keratinocytes; highly expressed in psoriatic skin.,
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