Price range: $268.00 through $328.00
Background:
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016],
| Size | 50μL/100μL |
| Target | FAN1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 112kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FAN1 AA range: 801-851 |
| Specificity | This antibody detects endogenous levels of FAN1 at Human/Mouse |
| Gene Name | FAN1 KIAA1018 MTMR15 |
| Protein Name | FAN1 |
| Other Name | |
| Species | Human |
| Gene ID | 22909 |
| Uniprot | Q9Y2M0, |
| Species.1 | Mouse |
| Gene ID.1 | 330554 |
| Uniprot.1 | Q69ZT1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Fanconi anemia pathway |
| Function | similarity:Belongs to the MTMR15 family., |
