Name: FANCL Polyclonal Antibody
SKU: WP1100
Price: 268 USD
Availability: InStock

FANCL Polyclonal Antibody

Ucallm_WP1100-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP1100-100

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Product details

Background:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	FANCL
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	41kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from part region of human protein
Specificity	FANCL Polyclonal Antibody detects endogenous levels of protein.
Gene Name	FANCL PHF9
Protein Name	E3 ubiquitin-protein ligase FANCL (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43)
Other Name
Species	Human
Gene ID	55120
Uniprot	Q9NW38,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q9CR14
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm. Nucleus.
Tissue Expression	Brain,Eye,Teratocarcinoma,
Signaling_pathway	Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
Research Areas	>>Fanconi anemia pathway; / >>Ubiquitin mediated proteolysis
Function	Caution:Although PubMed:12724401 reports that it contains a PHD-type zinc finger, it contains a RING-type zinc finger. Moreover, PHD-type zinc fingers do not have any ubiquitin ligase activity.,Disease:Defects in FANCL are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.,Function:Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with GGN (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients.,

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FANCL Polyclonal Antibody

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FANCL Polyclonal Antibody

Product details

Specifications

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