Product details
Background:
FAPP2 rabbit pAb
Ucallm_WP6670-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | PLEKHA8 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 57kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human FAPP2 |
| Specificity | This antibody detects endogenous levels of FAPP2 at Human, Mouse,Rat |
| Gene Name | PLEKHA8 FAPP2 |
| Protein Name | Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86) |
| Other Name | |
| Species | Human |
| Gene ID | 84725 |
| Uniprot | Q96JA3, |
| Species.1 | Mouse |
| Gene ID.1 | 231999 |
| Uniprot.1 | Q80W71, |
| Species.2 | Rat |
| Gene ID.2 | 500132 |
| Uniprot.2 | D3ZY60 |
| Cellular Localization | Golgi apparatus, trans-Golgi network membrane . Membrane; Peripheral membrane protein . Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. . |
| Tissue Expression | Expressed in kidney cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. |
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