Name: Ferritin Light Chain mouse mAb
SKU: WM0717
Price: 268 USD
Availability: InStock

Product details

Background:
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Ferritin Light Chain
Reactivity	Human
Applications	ELISA
MW(Calculated)
MW(Observed)	26kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:10000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	8C10
Immunogen	Purified recombinant full length of human ferritin light chain protein expressed in E.coli.
Specificity	This antibody detects recombinant ferritin proteins.
Gene Name	ftl
Protein Name
Other Name	Ferritin L chain; / Ferritin L subunit; / Ferritin light chain; / Ferritin light polypeptide; / Ferritin light polypeptide like 3; / FRIL; / FRIL_HUMAN; / FTL; / L apoferritin; / LFTD; / MGC71996; / NBIA 3; / NBIA3.
Species	Human
Gene ID	2512
Uniprot	P02792
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	cell,cytoplasm,cytosol,intracellular ferritin complex,membrane,autolysosome,extracellular exosome,
Tissue Expression	Brain,Colon endothelium,Kidney,Liver,Placenta,Skin,Testis,Urinary bladder,
Signaling_pathway	Cellular Processes >> Cell growth and death >> Ferroptosis;Cellular Processes >> Cell growth and death >> Necroptosis
Research Areas	>>Ferroptosis; / >>Necroptosis; / >>Mineral absorption
Function	Disease:Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.,Disease:Defects in FTL are the cause of neuroferritinopathy [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.,