FGF-18 Polyclonal Antibody
Ucallm_WP15259-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | FGF-18 |
| Reactivity | Human, Mouse, Rat, Sheep |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF18. AA range:158-207 |
| Specificity | FGF-18 Polyclonal Antibody detects endogenous levels of FGF-18 protein. |
| Gene Name | FGF18 |
| Protein Name | Fibroblast growth factor 18 |
| Other Name | FGF18; / Fibroblast growth factor 18; / FGF-18; / zFGF5 |
| Species | Human |
| Gene ID | 8817 |
| Uniprot | O76093, |
| Species.1 | Mouse |
| Gene ID.1 | 14172 |
| Uniprot.1 | O89101, |
| Species.2 | Rat |
| Gene ID.2 | 29369 |
| Uniprot.2 | O88182 |
| Cellular Localization | Secreted . |
| Tissue Expression | Lung,Ovary, |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Melanoma;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Ras signaling pathway;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Ras signaling pathway; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>PI3K-Akt signaling pathway; / >>Regulation of actin cytoskeleton; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Melanoma; / >>Breast cancer; / >>Gastric cancer |
| Function | Function:Stimulates hepatic and intestinal proliferation.,similarity:Belongs to the heparin-binding growth factors family., |
Please login to post questions
Related products
