SKU: WP12338 Categories: ,

FoxE1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12338-100
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Product details

Background:

This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetFoxE1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)34kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TTF2. AA range:10-59
SpecificityFoxE1 Polyclonal Antibody detects endogenous levels of FoxE1 protein.
Gene NameFOXE1
Protein NameForkhead box protein E1
Other NameFOXE1; / FKHL15; / FOXE2; / TITF2; / TTF2; / Forkhead box protein E1; / Forkhead box protein E2; / Forkhead-related protein FKHL15; / HFKH4; / HNF-3/fork head-like protein 5; / HFKL5; / Thyroid transcription factor 2; / TTF-2
SpeciesHuman
Gene ID2304
UniprotO00358,
Species.1Mouse
Gene ID.1110805
Uniprot.1Q8R2I0
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus .
Tissue ExpressionDetected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.
Signaling_pathway
Research Areas
FunctionDisease:Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome [MIM:241850]. A disease associated with thyroid agenesis, cleft palate and choanal atresia.,Function:Probable transcription factor. Could be involved in thyroid gland organogenesis.,polymorphism:An alanine stretch that varies from 12 to 19 residues is present. This polymorphisms can be used as a marker to study the role of FOXE1 in other cases of thyroid dysgenesis, especially in familial cases.,PTM:Phosphorylated.,sequence Caution:Several conflicts.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.,
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