FOXP1 Polyclonal Antibody
Ucallm_WP15287-50
Price range: $268.00 through $328.00
Product details
Background:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | FOXP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP1. AA range:628-677 |
| Specificity | FOXP1 Polyclonal Antibody detects endogenous levels of FOXP1 protein. |
| Gene Name | FOXP1 |
| Protein Name | Forkhead box protein P1 |
| Other Name | FOXP1; / HSPC215; / Forkhead box protein P1 |
| Species | Human |
| Gene ID | 27086 |
| Uniprot | Q9H334, |
| Species.1 | Mouse |
| Gene ID.1 | 108655 |
| Uniprot.1 | P58462, |
| Species.2 | Rat |
| Gene ID.2 | 297480 |
| Uniprot.2 | Q498D1 |
| Cellular Localization | Nucleus . Not found in the nucleolus. . |
| Tissue Expression | Isoform 8 is specifically expressed in embryonic stem cells. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> MicroRNAs in cancer |
| Research Areas | >>MicroRNAs in cancer |
| Function | Alternative products:Additional isoforms seem to exist,Disease:A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9; 3)(p13; p14.1) with PAX5.,Domain:The leucine-zipper is required for dimerization and transcriptional repression.,Function:Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1., |
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