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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/GBRT rabbit pAb
SKU: WP3867 Categories: ,

GBRT rabbit pAb

Ucallm_WP3867-50

Price range: $268.00 through $328.00

SKU: WP3867-100
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Product details

Background:

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009],

Specifications

Size50μL/100μL
TargetGBRT
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)70kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human GBRT AA range: 317-367
SpecificityThis antibody detects endogenous levels of GBRT at Human/Mouse
Gene NameGABRQ
Protein NameGBRT
Other Name
SpeciesHuman
Gene ID55879
UniprotQ9UN88,
Species.1Mouse
Gene ID.157249
Uniprot.1Q9JLF1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Expression
Signaling_pathway
Research Areas>>Neuroactive ligand-receptor interaction; / >>Retrograde endocannabinoid signaling; / >>GABAergic synapse; / >>Morphine addiction; / >>Nicotine addiction
FunctionFunction:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.,
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