Product details
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GEFT rabbit pAb
Ucallm_WP6098-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ARHGEF25 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 64kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GEFT |
| Specificity | This antibody detects endogenous levels of GEFT at Human, Mouse,Rat |
| Gene Name | ARHGEF25 GEFT |
| Protein Name | Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF) |
| Other Name | |
| Species | Human |
| Gene ID | 115557 |
| Uniprot | Q86VW2, |
| Species.1 | Mouse |
| Gene ID.1 | 52666 |
| Uniprot.1 | Q9CWR0, |
| Species.2 | Rat |
| Gene ID.2 | 314904 |
| Uniprot.2 | Q6P720 |
| Cellular Localization | Cell membrane . Cytoplasm, myofibril, sarcomere . Highly colocalizes with actin regions. |
| Tissue Expression | Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). |
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