Price range: $268.00 through $328.00
Background:
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008],
| Size | 50μL/100μL |
| Target | GFPT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 77kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GFPT1 AA range: 198-248 |
| Specificity | This antibody detects endogenous levels of GFPT1 at Human/Mouse/Rat |
| Gene Name | GFPT1 GFAT GFPT |
| Protein Name | GFPT1 |
| Other Name | |
| Species | Human |
| Gene ID | 2673 |
| Uniprot | Q06210, |
| Species.1 | Mouse |
| Gene ID.1 | 14583 |
| Uniprot.1 | P47856, |
| Species.2 | Rat |
| Gene ID.2 | 297417 |
| Uniprot.2 | P82808 |
| Cellular Localization | cytosol,extracellular exosome, |
| Tissue Expression | Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. |
| Signaling_pathway | |
| Research Areas | >>Alanine, aspartate and glutamate metabolism; / >>Amino sugar and nucleotide sugar metabolism; / >>Metabolic pathways; / >>Biosynthesis of nucleotide sugars; / >>Insulin resistance; / >>Diabetic cardiomyopathy |
| Function | Catalytic activity:L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.,Function:Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.,pathway:Nucleotide-sugar biosynthesis; UDP-N-acetyl-D-glucosamine biosynthesis; D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.,similarity:Contains 1 glutamine amidotransferase type-2 domain.,similarity:Contains 2 SIS domains.,subunit:Homotetramer .,tissue specificity:Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle., |
