Product details
Background:
GGA1 rabbit pAb
Ucallm_WP8328-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | GGA1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 70kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human GGA1 |
| Specificity | This antibody detects endogenous levels of GGA1 at Human, Mouse |
| Gene Name | GGA1 |
| Protein Name | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 26088 |
| Uniprot | Q9UJY5, |
| Species.1 | Mouse |
| Gene ID.1 | 106039 |
| Uniprot.1 | Q8R0H9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network . |
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