GLRX1 Polyclonal Antibody
Ucallm_WP2741-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011],
Specifications
| Size | 50μL/100μL |
| Target | GLRX1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 11kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 40-120 |
| Specificity | GLRX1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GLRX GRX |
| Protein Name | Glutaredoxin-1 |
| Other Name | Glutaredoxin-1; / Thioltransferase-1; / TTase-1 |
| Species | Human |
| Gene ID | 2745 |
| Uniprot | P35754, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QUH0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9ESH6 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Blood,Brain,Lens,Liver,Skin,Spleen,Urinary bladder, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.,similarity:Belongs to the glutaredoxin family.,similarity:Contains 1 glutaredoxin domain., |
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