GST-Pi [ABT256] mouse mAb
Ucallm_WM1563-50
Price range: $268.00 through $328.00
Product details
Background:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | GST-Pi |
| Reactivity | Human, Mouse |
| Applications | IHC, ELISA |
| MW(Calculated) | 23kD |
| MW(Observed) | 23kD |
| Host Species | Mouse |
| Isotype | IgG2b,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM256 |
| Immunogen | Synthesized peptide derived from human GST-Pi AA range: 150-210 |
| Specificity | The antibody can specifically recognize human GST-Pi protein. |
| Gene Name | GSTP1 FAEES3 GST3 |
| Protein Name | Deafness; Deafness X-linked 7; DFN7; FAEES3; Fatty Acid Ethyl Ester Synthase III; Glutathione S Transferase 3; Glutathione S Transferase Pi; Glutathione S-transferase P; Glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; Gstp1; GSTP1-1; GSTP1_HUMAN; PI; X linked 7 |
| Other Name | Deafness; / Deafness X-linked 7; / DFN7; / FAEES3; / Fatty Acid Ethyl Ester Synthase III; / Glutathione S Transferase 3; / Glutathione S Transferase Pi; / Glutathione S-transferase P; / Glutathione S-transferase pi 1; / GST class-pi; / GST3; / GSTP; / Gstp1; / GSTP1-1; / GSTP1_HUMAN; / PI; / X linked 7 |
| Species | Human |
| Gene ID | 2950 |
| Uniprot | P09211, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P19157, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P04906 |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Esophageal squamous cell carcinoma |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Prostate cancer |
| Research Areas | >>Glutathione metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Platinum drug resistance; / >>Pathways in cancer; / >>Chemical carcinogenesis - DNA adducts; / >>Prostate cancer; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis |
| Function | Catalytic activity:RX + glutathione = HX + R-S-glutathione.,Function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the GST superfamily. Pi family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer., |
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