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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/GSTA1 Polyclonal Antibody
SKU: WP15906 Categories: ,

GSTA1 Polyclonal Antibody

Ucallm_WP15906-50

Price range: $268.00 through $328.00

SKU: WP15906-100
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Product details

Background:

This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Specifications

TargetGSTA1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IP, IHC, IF, ELISA
MW(Calculated)26kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human GSTA1. AA range:91-140
Sequence
SpecificityThe antibody detects endogenous GSTA1
Gene NameGSTA1
Protein NameGlutathione S-transferase A1 (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1)
Other NameGlutathione S-transferase A1; / GST HA subunit 1; / GST class-alpha member 1; / GST-epsilon; / GSTA1-1; / GTH1
SpeciesHuman
Gene ID-12938
UniprotP08263,
Species.1Mouse
Gene ID-214857
Uniprot.1P13745,
Species.2Rat
Gene ID-3
Uniprot.2P00502
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Cellular LocalizationCytoplasm.
Tissue ExpressionLiver.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Research Areas>>Glutathione metabolism; / >>Metabolism of xenobiotics by cytochrome P450; / >>Drug metabolism - cytochrome P450; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Platinum drug resistance; / >>Pathways in cancer; / >>Chemical carcinogenesis - DNA adducts; / >>Chemical carcinogenesis - receptor activation; / >>Chemical carcinogenesis - reactive oxygen species; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis
FunctionCatalytic activity:RX + glutathione = HX + R-S-glutathione.,Domain:The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.,Function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,similarity:Belongs to the GST superfamily.,similarity:Belongs to the GST superfamily. Alpha family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer or heterodimer of GSTA1 and GSTA2.,tissue specificity:Liver.,
RRID
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