Product details
Background:
HMGCR rabbit pAb
Ucallm_WP5984-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | HMGCR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 98kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human HMGCR |
| Specificity | This antibody detects endogenous levels of HMGCR at Human, Mouse,Rat |
| Gene Name | HMGCR |
| Protein Name | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) |
| Other Name | |
| Species | Human |
| Gene ID | 3156 |
| Uniprot | P04035, |
| Species.1 | Mouse |
| Gene ID.1 | 15357 |
| Uniprot.1 | Q01237, |
| Species.2 | Rat |
| Gene ID.2 | 25675 |
| Uniprot.2 | P51639 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . Peroxisome membrane; Multi-pass membrane protein . |
| Tissue Expression | [Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland.; [Isoform 2]: Detected in the cerebellum, fetal brain, testis and adrenal gland.; [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> AMPK signaling pathway |
| Research Areas | |
| Function | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis . HMGCR is the main target of statins, a class of cholesterol-lowering drugs . |
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