Product details
Background:
HOOK3 rabbit pAb
Ucallm_WP6176-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | HOOK3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 79kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human HOOK3 |
| Specificity | This antibody detects endogenous levels of HOOK3 at Human, Mouse |
| Gene Name | HOOK3 |
| Protein Name | Protein Hook homolog 3 (h-hook3) (hHK3) |
| Other Name | |
| Species | Human |
| Gene ID | 84376 |
| Uniprot | Q86VS8, |
| Species.1 | Mouse |
| Gene ID.1 | 320191 |
| Uniprot.1 | Q8BUK6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Golgi apparatus . Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase (PubMed:11238449). Localizes to the manchette in elongating spermatids (By similarity). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) . FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell .; (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. |
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