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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/I12R2 Polyclonal Antibody
SKU: WP2170 Categories: ,

I12R2 Polyclonal Antibody

Ucallm_WP2170-50

Price range: $268.00 through $328.00

SKU: WP2170-100
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Product details

Background:

interleukin 12 receptor subunit beta 2(IL12RB2) Homo sapiens The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012],

Specifications

Size50μL/100μL
TargetI12R2
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)94kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 270-350
SpecificityI12R2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameIL12RB2
Protein NameInterleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Other Name
SpeciesHuman
Gene ID3595
UniprotQ99665,
Species.1Mouse
Gene ID.1
Uniprot.1P97378
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue ExpressionIsoform 2 is expressed at similar levels in both naive and activated T-cells.
Signaling_pathwayOrganismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Inflammatory bowel disease;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas>>Cytokine-cytokine receptor interaction; / >>JAK-STAT signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Pathways in cancer; / >>Inflammatory bowel disease
Functiondevelopmental stage:Maximum levels in Th1 cells between day 3 and day 8 of activation.,Domain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.,induction:In vitro, up-regulated by interferon alpha.,polymorphism:Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.,PTM:On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 5 fibronectin type-III domains.,subunit:Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.,tissue specificity:Isoform 2 is expressed at similar levels in both naive and activated T-cells.,
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