Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | IL-1F5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 17kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL36RN. AA range:1-50 |
| Specificity | IL-1F5 Polyclonal Antibody detects endogenous levels of IL-1F5 protein. |
| Gene Name | IL36RN |
| Protein Name | Interleukin-36 receptor antagonist protein |
| Other Name | IL36RN; / FIL1D; / IL1F5; / IL1HY1; / IL1L1; / IL1RP3; / Interleukin-36 receptor antagonist protein; / FIL1 delta; / IL-1-related protein 3; / IL-1RP3; / Interleukin-1 HY1; / IL-1HY1; / Interleukin-1 delta; / IL-1 delta; / Interleukin-1 family member 5; / IL-1F5; / Interleukin-1 receptor antagonist homolog 1; / IL-1ra homolog 1; / Interleukin-1-like protein 1; / IL-1L1 |
| Species | Human |
| Gene ID | 26525 |
| Uniprot | Q9UBH0, |
| Species.1 | Mouse |
| Gene ID.1 | 54450 |
| Uniprot.1 | Q9QYY1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Secreted . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. . |
| Tissue Expression | Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction |
| Function | Function:Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.,induction:By phorbol ester (PMA) and lipopolysaccharide (LPS) treatment in macrophage cell line.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,tissue specificity:Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin., |
