IL-8Rβ Polyclonal Antibody
Ucallm_WP15440-50
Price range: $268.00 through $328.00
Product details
Background:
C-X-C motif chemokine receptor 2(CXCR2) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as
Specifications
| Size | 50μL/100μL |
| Target | IL-8Rβ |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human CXCR2. AA range:1-50 |
| Specificity | IL-8Rβ Polyclonal Antibody detects endogenous levels of IL-8Rβ protein. |
| Gene Name | CXCR2 |
| Protein Name | C-X-C chemokine receptor type 2 |
| Other Name | CXCR2; / IL8RB; / C-X-C chemokine receptor type 2; / CXC-R2; / CXCR-2; / CDw128b; / GRO/MGSA receptor; / High affinity interleukin-8 receptor B; / IL-8R B; / IL-8 receptor type 2; / CD182 |
| Species | Human |
| Gene ID | 3579 |
| Uniprot | P25025, |
| Species.1 | Mouse |
| Gene ID.1 | 12765 |
| Uniprot.1 | P35343 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain,Placenta, |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>Viral protein interaction with cytokine and cytokine receptor; / >>Chemokine signaling pathway; / >>Phospholipase D signaling pathway; / >>Endocytosis; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Human cytomegalovirus infection |
| Function | Function:Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.,online information:CXC chemokine receptors entry,PTM:Phosphorylated upon ligand binding; which is required for desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family., |
Please login to post questions
Related products
