Name: Integrin αL Polyclonal Antibody
SKU: WP15582
Price: 268 USD
Availability: InStock

Product details

Background:

integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Target	Integrin αL
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	130kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human ITGAL. AA range:171-220
Sequence
Specificity	Integrin αL Polyclonal Antibody detects endogenous levels of Integrin αL protein.
Gene Name	ITGAL
Protein Name	Integrin alpha-L
Other Name	ITGAL; / CD11A; / Integrin alpha-L; / CD11 antigen-like family member A; / Leukocyte adhesion glycoprotein LFA-1 alpha chain; / LFA-1A; / Leukocyte function-associated molecule 1 alpha chain; / CD11a
Species	Human
Gene ID-1	3683
Uniprot	P20701,
Species.1	Mouse
Gene ID-2
Uniprot.1	P24063
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Cellular Localization	Cell membrane; Single-pass type I membrane protein .
Tissue Expression	Leukocytes.
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Rap1 signaling pathway; / >>Cell adhesion molecules; / >>Neutrophil extracellular trap formation; / >>Natural killer cell mediated cytotoxicity; / >>Leukocyte transendothelial migration; / >>Regulation of actin cytoskeleton; / >>Malaria; / >>Staphylococcus aureus infection; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Rheumatoid arthritis; / >>Viral myocarditis
Function	Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes.,
RRID

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Integrin αL Polyclonal Antibody

Product details

Specifications

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Integrin αL Polyclonal Antibody

Product details

Specifications

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