Name: Integrin β2 Polyclonal Antibody
SKU: WP15491
Price: 268 USD
Availability: InStock

Product details

Background:

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

Specifications

Target	Integrin β2
Reactivity	Human, Mouse
Applications	WB, IHC
MW(Calculated)
MW(Observed)	95kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human ITGB2. AA range:621-670
Sequence
Specificity	Integrin β2 Polyclonal Antibody detects endogenous levels of Integrin β2 protein.
Gene Name	ITGB2
Protein Name	Integrin beta-2
Other Name	ITGB2; / CD18; / MFI7; / Integrin beta-2; / Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; / Complement receptor C3 subunit beta; / CD18
Species	Human
Gene ID-1	3689
Uniprot	P05107,
Species.1	Mouse
Gene ID-2
Uniprot.1	P11835
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Membrane raft; Single-pass type I membrane protein .
Tissue Expression	Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Complement and coagulation cascades;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Rap1 signaling pathway; / >>Phagosome; / >>Hippo signaling pathway; / >>Cell adhesion molecules; / >>Complement and coagulation cascades; / >>Neutrophil extracellular trap formation; / >>Natural killer cell mediated cytotoxicity; / >>Leukocyte transendothelial migration; / >>Regulation of actin cytoskeleton; / >>Pertussis; / >>Legionellosis; / >>Leishmaniasis; / >>Malaria; / >>Amoebiasis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Human T-cell leukemia virus 1 infection; / >>Rheumatoid arthritis; / >>Viral myocarditis
Function	Disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,Function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.,similarity:Belongs to the integrin beta chain family.,similarity:Contains 1 VWFA domain.,subunit:Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.,
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Integrin β2 Polyclonal Antibody

Product details

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Integrin β2 Polyclonal Antibody

Product details

Specifications

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