Price range: $268.00 through $328.00
Background:
IQ motif containing GTPase activating protein 2(IQGAP2) Homo sapiens This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | IQGA2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 173kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 200-280 |
| Specificity | IQGA2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | IQGAP2 |
| Protein Name | Ras GTPase-activating-like protein IQGAP2 |
| Other Name | |
| Species | Human |
| Gene ID | 10788 |
| Uniprot | Q13576, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q3UQ44 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytoplasm,cytosol,microtubule,microvillus,cell surface,actin cytoskeleton,lamellipodium,filopodium,filamentous actin,extracellular exosome, |
| Tissue Expression | Isoform 2 expression is enhanced in testis. |
| Signaling_pathway | Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton |
| Research Areas | >>Regulation of actin cytoskeleton |
| Function | Function:Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 1 WW domain.,similarity:Contains 3 IQ domains.,tissue specificity:Isoform 2 expression is enhanced in testis., |
