Product details
Background:
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IREB2 rabbit pAb
Ucallm_WP3672-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | IREB2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human IREB2 AA range: 702-752 |
| Specificity | This antibody detects endogenous levels of IREB2 at Human/Mouse/Rat |
| Gene Name | IREB2 |
| Protein Name | IREB2 |
| Other Name | Iron-responsive element-binding protein 2; / IRE-BP 2; / Iron regulatory protein 2; / IRP2 |
| Species | Human |
| Gene ID | 3658 |
| Uniprot | P48200, |
| Species.1 | Mouse |
| Gene ID.1 | 64602 |
| Uniprot.1 | Q811J3, |
| Species.2 | Rat |
| Gene ID.2 | 64831 |
| Uniprot.2 | Q62751 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Brain, |
| Signaling_pathway | |
| Research Areas | |
| Function | cofactor:Binds 1 4Fe-4S cluster per subunit.,Function:Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.,similarity:Belongs to the aconitase/IPM isomerase family., |
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