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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ITGA5 (heavy chain, Cleaved-Arg894) rabbit pAb
SKU: WP0159 Categories: ,

ITGA5 (heavy chain, Cleaved-Arg894) rabbit pAb

Ucallm_WP0159-50

Price range: $268.00 through $328.00

SKU: WP0159-100
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Product details

Background:

function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,

Specifications

Size50μL/100μL
TargetIntegrin α5
ReactivityHuman, Mouse
ApplicationsWB, ELISA, IHC
MW(Calculated)
MW(Observed)94kD,110kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)
SpecificityThis antibody detects endogenous levels of Human,Mouse ITGA5 (heavy chain, Cleaved-Arg894, protein was cleaved amino acid sequence between 894-895 )
Gene NameITGA5 FNRA
Protein NameITGA5 (heavy chain, Cleaved-Arg894)
Other NameIntegrin alpha-5; / CD49 antigen-like family member E; / Fibronectin receptor subunit alpha; / Integrin alpha-F; / VLA-5; / CD antigen CD49e; / [Cleaved into: Integrin alpha-5 heavy chain; / Integrin alpha-5 light chain]
SpeciesHuman
Gene ID3678
UniprotP08648,
Species.1Mouse
Gene ID.116402
Uniprot.1P11688
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .
Tissue Expression
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction
Research Areas>>Phagosome; / >>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>ECM-receptor interaction; / >>Hematopoietic cell lineage; / >>Regulation of actin cytoskeleton; / >>Bacterial invasion of epithelial cells; / >>Shigellosis; / >>Pertussis; / >>Yersinia infection; / >>Human papillomavirus infection; / >>Herpes simplex virus 1 infection; / >>Proteoglycans in cancer; / >>MicroRNAs in cancer; / >>Hypertrophic cardiomyopathy; / >>Arrhythmogenic right ventricular cardiomyopathy; / >>Dilated cardiomyopathy
Functioncell motion, cell-substrate junction assembly, cell adhesion, heterophilic cell adhesion, leukocyte adhesion, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, behavior, learning or memory, memory,response to wounding, cell-cell adhesion, cell migration, biological adhesion, cell adhesion mediated by integrin, cell-cell adhesion mediated by integrin, cell junction assembly, cell junction organization, wound healing, spreading of epidermal cells, wound healing, cell motility, neurological system process, cognition, localization of cell,
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