Kallistatin Polyclonal Antibody
Ucallm_WP15290-50
Price range: $268.00 through $328.00
Product details
Background:
function:Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein., miscellaneous:Heparin blocks kallistatin’s complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein’s activity., PTM:The N-terminus is blocked., similarity:Belongs to the serpin family., subunit:Monomer and some homodimers., tissue specificity:Expressed by the liver and secreted in plasma.,
Specifications
| Size | 50μL/100μL |
| Target | Kallistatin |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SERPINA4. AA range:161-210 |
| Specificity | Kallistatin Polyclonal Antibody detects endogenous levels of Kallistatin protein. |
| Gene Name | SERPINA4 |
| Protein Name | Kallistatin |
| Other Name | SERPINA4; / KST; / PI4; / Kallistatin; / Kallikrein inhibitor; / Peptidase inhibitor 4; / PI-4; / Serpin A4 |
| Species | Human |
| Gene ID | 5267 |
| Uniprot | P29622 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed by the liver and secreted in plasma. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.,miscellaneous:Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.,PTM:The N-terminus is blocked.,similarity:Belongs to the serpin family.,subunit:Monomer and some homodimers.,tissue specificity:Expressed by the liver and secreted in plasma., |
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