KAT6B Polyclonal Antibody
Ucallm_WP0565-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],
Specifications
| Size | 50μL/100μL |
| Target | KAT6B |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 228kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1170-1250 |
| Specificity | KAT6B Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KAT6B KIAA0383 MORF MOZ2 MYST4 |
| Protein Name | Histone acetyltransferase KAT6B (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) |
| Other Name | |
| Species | Human |
| Gene ID | 23522 |
| Uniprot | Q8WYB5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BRB7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,Disease:A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10; 16)(q22; p13) with CREBBP.,Domain:The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.,Function:Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.,PTM:Autoacetylated.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the MYST (SAS/MOZ) family.,similarity:Contains 1 C2HC-type zinc finger.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Component of the MOZ/MORF composed at least of ING5, MYST3/MOZ, MYST4/MORF and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1 and RUNX2.,tissue specificity:Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary., |
Please login to post questions
Related products
