SKU: WP12926 Categories: ,

KIR3.3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12926-100
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Product details

Background:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKIR3.3
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)44kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human KCNJ9. AA range:61-110
SpecificityKIR3.3 Polyclonal Antibody detects endogenous levels of KIR3.3 protein.
Gene NameKCNJ9
Protein NameG protein-activated inward rectifier potassium channel 3
Other NameKCNJ9; / GIRK3; / G protein-activated inward rectifier potassium channel 3; / GIRK-3; / Inward rectifier K; / +; / channel Kir3.3; / Potassium channel; / inwardly rectifying subfamily J member 9
SpeciesHuman
Gene ID3765
UniprotQ92806,
Species.1Mouse
Gene ID.116524
Uniprot.1P48543,
Species.2Rat
Gene ID.2116560
Uniprot.2Q63511
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue Expression
Signaling_pathwayOrganismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse
Research Areas>>Circadian entrainment; / >>Retrograde endocannabinoid signaling; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Estrogen signaling pathway; / >>Oxytocin signaling pathway; / >>GnRH secretion; / >>Morphine addiction
FunctionFunction:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit.,
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