Name: Kir4.1 rabbit pAb
SKU: WP17657
Price: 268 USD
Availability: InStock

Kir4.1 rabbit pAb

Ucallm_WP17657-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP17657-100

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Product details

Background:

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Kir4.1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC
MW(Calculated)	42kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human Kir4.1 AA range: 160-240
Specificity	This antibody detects endogenous levels of Human,Rat,Mouse Kir4.1
Gene Name	KCNJ10
Protein Name	Kir4.1
Other Name	ATP-sensitive inward rectifier potassium channel 10; / ATP-dependent inwardly rectifying potassium channel Kir4.1; / Inward rectifier K; / +; / channel Kir1.2; / Potassium channel, inwardly rectifying subfamily J member 10
Species	Human
Gene ID	3766
Uniprot	P78508,
Species.1	Mouse
Gene ID.1	16513
Uniprot.1	Q9JM63,
Species.2	Rat
Gene ID.2	29718
Uniprot.2	P49655
Cellular Localization	Membrane; Multi-pass membrane protein. Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. .
Tissue Expression	Expressed in kidney (at protein level).
Signaling_pathway	Human Diseases >> Neurodegenerative disease >> Huntington disease
Research Areas	>>Gastric acid secretion; / >>Huntington disease
Function	Function:May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Seems to form heterodimer with Kir5.1/KCNJ16. Interacts with INADL.,